By J. W. Hopewell, W. Calvo, R. Jaenke, H. S. Reinhold, M. E. C. Robbins, E. M. Whitehouse (auth.), PD Dr. Wolfgang Hinkelbein, Dr. Gregor Bruggmoser, Prof. Dr. Hermann Frommhold, Prof. Dr. Michael Wannenmacher (eds.)
Biologists and radiotherapists current their experimental paintings and scientific information within the box of radiation accidents of standard tissues and organs. specific regard is payed to the relevance of organic mechanisms in scientific events. ideas of radiation harm and mixed therapy toxicity in radio-chemotherapy are being defined. the most themes mentioned are the significance of microvasculature, time, doseand fractionation and elements editing scientific radioresponse for early andlate radiation results. Tissues and organs thought of during this quantity are mucosa and epidermis, lung and center, bladder and muscle, CNS and eye. precise difficulties of pediatric radiotherapy, TBI, IORT and moment malignacies also are mentioned.
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Extra resources for Acute and Long-Term Side-Effects of Radiotherapy: Biological Basis and Clinical Relevance
1 and 3 are expressed as the RBE compared with an exponential response to neutrons given by E' = n(aNdN) in analogy with Eq. 1. Thus RBE = aN/aRES 1 + g exp( -d/de ) + d/(aRES/~) (5) The continuous line in Fig. 6 shows the excellent fit of this equation to the data. It appears, therefore, that a concept of induced repair, as implemented simply in Eq. 3, can adequately account for the phenomenon of unexpected radiosensitivity to low X-ray doses, which we have seen both in vivo and in vitro. Interestingly, low-dose sensitivity does not appear to be a feature of the response to neutrons either in vitro (Fig.
Unpublished) (Fig. 2); and Johns (1988) (Fig. 3); Marples and Joiner (1992) (Fig. 6) e Joiner this is the explanation for this phenomenon, is triggered by specific types of DNA lesion which dominate at low LET - for example single- and doublestrand breaks. Table 1 summarizes the values of g and de obtained from the fits of Eqs. 4 and 5 to the data from the different systems. Interestingly, g is highest in the kidney; this tissue is late-reacting with the lowest value of a/~ of these systems. 4 Gy but do vary between systems and even, in the skin, between experiments.
2MeV a-particles with respect to X-rays (Bedford and Goodhead 1989), was in contrast to the much higher RBE of about 10 for the subsequent production of chromosome-type exchange aberrations observed at mitosis. With respect to double-strand breaks in DNA, the lesions responsible for subsequent chromosome exchanges and fragments, a slower rate of rejoining, and a greater proportion of breaks unrepaired (by the last sampling time) have been reported after a-radiation than after low-LET irradiation (Blocher 1988; Frankenberg-Schwager et al.
Acute and Long-Term Side-Effects of Radiotherapy: Biological Basis and Clinical Relevance by J. W. Hopewell, W. Calvo, R. Jaenke, H. S. Reinhold, M. E. C. Robbins, E. M. Whitehouse (auth.), PD Dr. Wolfgang Hinkelbein, Dr. Gregor Bruggmoser, Prof. Dr. Hermann Frommhold, Prof. Dr. Michael Wannenmacher (eds.)